While the research on most supplements for joint pain is mixed, and the FDA doesn’t regulate supplements, fish oil, glucosamine, and chondroitin are among those that will assist manage it. Dozens of supplements declare to treat joint ache, along with typical ache relievers like acetaminophen and ibuprofen, but which ones really work? Here, we take a look at 9 options and what current research says about them. Supplements usually are not Food and Drug Administration (FDA) permitted. Speak along with your physician memory and focus supplement a registered dietitian earlier than taking any and only purchase from trusted sellers. Turmeric is one of the most well-liked supplements for treating pain, including joint ache attributable to osteoarthritis (OA). Its ache-relieving results are attributed to a chemical compound in turmeric known as curcumin. Curcumin could have anti-inflammatory effects. Although research on turmeric for joint pain is proscribed, a 2021 research overview of 10 research discovered that supplementation with turmeric or curcumin extract improves knee OA joint pain in comparison with a placebo.
More research is needed on the dosing, frequency, and formulation of those supplements. But 500 to 1,500 milligrams (mg) daily for 3 months has shown promising ends in research. A 4-month, randomized research revealed in 2020 discovered that fish oil supplements considerably reduce OA-particular pain and improve effectively-being. But more analysis is required. The National Institutes of Health (NIH) recommends 1,600 mg daily for males and 1,100 mg daily for girls. Glucosamine is a natural brain health supplement part of cartilage, a substance that prevents bones from rubbing against one another and causing ache and inflammation. It may additionally assist forestall the cartilage breakdown that may occur with arthritis. Many joint pain supplements include glucosamine (as both glucosamine sulfate or glucosamine hydrochloride), some of the well-studied supplements for osteoarthritis. Despite this analysis, findings have been inconsistent. A 2018 research evaluation of 29 studies cited some research that found glucosamine improved knee OA ache and others that discovered little to no improvement in joint ache.
Glucosamine sulfate is typically taken once daily in a dose of 1,500 mg. If this upsets your stomach, unfold it out over three doses of 500 mg every. Like glucosamine, chondroitin is a building block of cartilage. It may also help prevent cartilage breakdown from OA. Many studies have found that chondroitin might reduce joint ache, stiffness, and inflammation in people with OA. Chondroitin sulfate may also slow the progression of OA by limiting joint area narrowing. Joint supplements usually combine chondroitin with glucosamine. But it’s nonetheless unclear if taking a mix supplement is any better than taking one or the other alone. A 2018 research assessment discovered that glucosamine or chondroitin supplementation lowered joint ache when taken separately and not together. Chondroitin suggestions can differ from 800 mg to 1,200 mg. Chances are you'll take this as a single dose or in 400 mg doses 2 to 3 occasions.
Your liver naturally produces S-adenosyl-L-methionine (Same) from an amino acid called methionine. Current research on the good thing about Same for joint pain is lacking, and the prevailing research is inconsistent. A 2009 clinical trial of Korean contributors found that very same didn’t relieve pain greater than another remedy after 8 weeks. In past studies, Same was often taken in doses of 800 mg every day. It may take a while to notice the outcomes. Boswellia, or Indian frankincense, is usually used to deal with arthritis pain. Its extract comprises chemicals called Boswellia acids, which may have anti-inflammatory and anti-arthritic results. A 2020 animal study discovered that Boswellic acids relieve OA pain and protect cartilage. More human analysis is needed to further support its use for joint pain. The NIH recommends 250 to 500 mg of Boswellia serrata 2 or three instances each day. Avocado-soybean unsaponifiables (ASUs) seek advice from an extract from avocado and soybean oils which will assist prevent cartilage breakdown and memory and focus supplement restore it. A 2018 examine in rats found that treatment with ASU lessened joint pain.
These findings level to the use of ASUs for joint inflammation and ache associated with end stage OA, however extra research in humans is required. 300 mg of ASUs day by day could also be a great beginning dose. Devil’s claw, additionally called harpagophytum, contains a chemical called harpogoside, which may have anti-arthritic and anti-osteoporosis effects. A 2022 mouse mannequin examine discovered that it might sluggish bone erosion from inflammatory arthritis. An older research published in 2000 discovered devil’s claw worked about in addition to an anti-inflammatory drug referred to as diacerein. However, latest human research on this complement for osteoarthritis is missing, so more prime quality studies are needed. It’s recommended to take 500 to 1,500 mg of devil’s claw dried root capsules three occasions each day. Methylsulfonylmethane (MSM) might have anti-inflammatory results. In a 2023 research of 88 participants in Japan with mild knee joint pain, 12 weeks of MSM supplementation led to significantly improved situations. Specifically, the research found that taking five 200 mg MSM tablets with breakfast and dinner improved knee and general properly-being in comparison with a placebo.